by Stuart Davis | Oct 26, 2019 | Bioinformatics
Trimming for adaptors and low quality bases is important part of the analysis pipeline for sequencing data. Typically, after you isolate and fragment your RNA sample, adaptors are attached to the ends of the sequences that are needed for sequencing (see [1,2] for more...
by Stuart Davis | Oct 23, 2019 | Announcements
The Eunice Kennedy Shriver National Institute of Child Health & Human Development recently awarded Basepair a $300,000 Small Business Innovation Research grant for the development of a software platform for pre-implantation genetic testing of aneuploidy (PGT-A). ...
by Stuart Davis | Aug 26, 2019 | Announcements
We are pleased to announce the release of our new pipeline for investigating changes in alternative splicing (AS) in RNA-seq. As a quick reminder, a gene may have many forms (isoforms) depending on which exons and transcription start sites are used for transcription....
by Stuart Davis | Jul 18, 2019 | Announcements
Key features We are pleased to announce the release of Basepair’s significantly updated single cell RNA-seq (scRNA-seq) pipeline. It brings many improvements in new features, efficiency, and user friendliness: 1. Seurat version 3 Version 3 of the scRNA-seq...
by Stuart Davis | Mar 5, 2019 | Bioinformatics
Background One of the most popular tools for pathway enrichment analysis for RNA-seq and microarray data is the Gene Set Enrichment Analysis (GSEA) tool by the Broad Institute [1,2]. The database of pathways most often used with GSEA is MSigDB, also by the Broad...
